January 14 - Treaty of Madrid . Peace between Francis I of France and Charles V. Francis agrees to cede Burgundy to Charles, and abandons all claims to Flanders, Artois, Naples, and Milan.
May 22 - Francis repudiates the Treaty of Madrid and forms the League of Cognac against Charles, including the Pope, Milan, Venice, and Florence.
First battle of Panipat - Babur becomes Moghul (or Mughal) emperor of India, captures Delhi, and invades Northern India, beginning the Mughal empire which would last until 1858.