SCP-ISM, or Screened Coulomb Potentials Implicit Solvent Model is a computer simulation used to simulate solvent effects on biological macromolecules, such as proteins and nucleic acids. It is based on the classic theory of polar liquids, as developed by Peter Debye and corrected by Lars Onsager to incorporate reaction field effects. The model can be combined with quantum chemical calculations to formally derive a continuum model of solvent effects suitable for computer simulations of small and large molecular systems.
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Last updated: 08-19-2006 14:43:24
